Tretizen 20 mg

Descrição do produto

Tretizen-20 é um medicamento usado para tratar acne grave que não responde a outros tratamentos, incluindo antibióticos. Este produto é fabricado pela farmacêutica Zen Labs e contém a substância ativa isotretinoína. 13-cis-o ácido retinóico (isotretinoína) foi sintetizado pela primeira vez em 1955. Além da acne, as indicações para o uso do medicamento são rosácea, dermatite perioral, dermatite seborreica, foliculite, granuloma anular, sarcoidose, diversos distúrbios de queratinização e fotoenvelhecimento.

Efeito da droga

Isotretinoin slows down the proliferation of epithelial cells of the ducts of the sebaceous glands, the formation of detritus, facilitates the evacuation of detritus, and normalizes terminal cell differentiation. Isotretinoin facilitates secretion and reduces sebum production. After oral administration, absorption of isotretinoin is variable, bioavailability is variable and low; taking isotretinoin with food increases bioavailability by 2 times. The maximum concentration in blood plasma is reached within 2 to 4 hours. Isotretinoin binds to plasma proteins by 99.9% (mainly with albumin). The half-life of isotretinoin is 19 hours. Isotretinoin is excreted in the bile and kidneys in approximately equal amounts.

 Dosagem

Isotretinoin by Zen Labs is taken orally. The dosage regimen is set individually, because the adverse reactions and therapeutic efficacy of isotretinoin depend on the dose and vary with each individual. The drug is taken with meals, the initial dose is 0.4 - 0.5 mg / kg per day, which is divided into two parts, and is used for 16 - 24 weeks. Depending on the severity of adverse reactions and response to treatment, dose adjustment is performed. If in 16 - 24 weeks the number of rashes has decreased by 70% or more, then the therapy is stopped. A repeated course of treatment is carried out upon confirmation of a recurrent or persistent course of the disease with an interval of at least 2 months.

Reações adversas

There is a high risk of side effects, so you should always think carefully about whether to use oral isotretinoin therapy in your case. The primary symptom is severe dryness of the skin, sore lips, itching and flaking of the skin on the hands and feet. Irritation may occur on the skin and mucous membranes, and in 30% of cases, patients complain of hair loss, which is reversible after the end of treatment. Dry skin is exacerbated by situations where it is exposed to sunlight. During therapy, you should completely abandon sunbathing, and in everyday life, use creams with high filters (at least Sun Protection Factor 50). Another unpleasant side effect is impaired liver function; therefore, the concentration of transaminases should be carefully monitored during therapy. In addition, adverse changes in the patient's lipid profile are often observed, which also need to be monitored regularly. In the Comprimidos de isotretinoína seção você pode ver produtos de outros fabricantes. Também recomendamos que você se familiarize com a seção completa do Pele. A entrega da isotretinoína para os EUA é realizada dentro de 5 a 12 dias úteis. Se você tiver alguma dúvida, sinta-se à vontade para entrar em contato com nossa equipe de atendimento ao cliente para obter ajuda.